(S)-3,4-DCPG (UBP1109)
mGlu8a agonistOther names: UBP1109 | |||||
Product Code: Asc-006 |
Purity: >99% |
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| Buy (S)-3,4-DCPG (UBP1109) from Abcam | ||||
Biological DescriptionPotent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7. Systemically active in vivo. |
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Useful References | |
(2001) (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 40:311 abstract (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40:732 abstract (2005) Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacol. 179:4 abstract | |
Citations | |
Lopez et al. (2007) Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease. J Neurosci. 27: 6701-11. abstract Beurrier et al. (2009) Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB 23:3619-3628 abstract mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner abstract | |
Chemical Information(S)-3,4-Dicarboxyphenylglycine | |
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