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Selective group I mGlu agonist

Product Code: Asc-007

Purity: >99%

Pack Size




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Biological Description

Selective group I mGlu agonist.

Also available in simple stock solutions (Asc-4484) - add 1 ml of water to get an exact, ready-to-use concentration.

Useful References

(2002) (S)-3,5-DHPG: a review.CNS Drug Rev. 8:101 abstract

(2005) Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacol. 179:4 abstract

(2005) Behavioral and convulsant effects of the (S) enantiomer of the group I metabotropic glutamate receptor agonist 3,5-DHPG in mice. Neuropharmacology 48:779-87 abstract


Topolnik et al. (2009) Activity-Dependent Compartmentalized Regulation of Dendritic Ca2+ Signaling in Hippocampal Interneurons. J Neurosci 29(14):4658-4663 abstract

Novel mGluR-and CB1R-Independent Suppression of GABA Release Caused by a Contaminant of the Group I Metabotropic Glutamate Receptor Agonist, … abstract

Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension abstract

Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization abstract

Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase‐activated receptor‐2 abstract

Excitatory modulation in the cochlear nucleus through group I metabotropic glutamate receptor activation abstract

Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous … abstract

Spinal Sensitization Mechanisms Promoting Pain: Gabaergic Disinhibition and Pkmζ-Mediated Plasticity abstract

Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity abstract

Depolarization-induced slow current in cerebellar Purkinje cells does not require metabotropic glutamate receptor 1 abstract

Purine receptor‐mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex abstract

Low hippocampal PI(4,5)P2 contributes to reduced cognition in old mice as a result of loss of MARCKS. abstract

Novel GABAergic Circuits Mediating Excitation/Inhibition of Cajal-Retzius Cells in the Developing Hippocampus abstract

Dendritic Generation of mGluR-Mediated Slow Afterdepolarization in Layer 5 Neurons of Prefrontal Cortex abstract

Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism abstract

Erg Potassium Currents of Neonatal Mouse Purkinje Cells Exhibit Fast Gating Kinetics and Are Inhibited by mGluR1 Activation abstract

Chemical Information


  • Desiccate at -20°C
  • MW 183.16
  • Soluble in water to 50 mM
  • C8H9NO4
  • 162870-29-3