(S)-5-Fluorowillardiine
Potent, selective AMPA agonistProduct Code: Asc-036 |
Purity: >99% |
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Biological DescriptionPotent, selective AMPA receptor agonist. Displays higher affinity than AMPA at hGluR1 and hGlurR2, and displays greater selectivity for AMPA receptor subtypes over the kainate receptor hGluR5. |
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Useful References | |
(1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J.Med.Chem. 40: 3645 abstract (1995) Binding of the new radioligand (S)-[3H]-AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine. Neuropharmacol. 34:405 abstract (1994) Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. J.Neurosci. 14: 3881 abstract | |
Citations | |
Mankiewicz et al (2008) Chemical interplay in the mechanism of partial agonist activation in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Biochemistry. 47:398-404. abstract Structure of the S1S2 glutamate binding domain of GluR3 abstract Probing the allosteric modulator binding site of GluR2 with thiazide derivatives abstract | |
Chemical Information(S)-2-Amino-3-(5-fluoro-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)propanoic acid | |
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