1400W

Selective iNOS inhibitor

Pack Size

Biological Description Selective iNOS inhibitor, 5000-fold selective over eNOS (K_d values are ≤7 nM, 2 μM and 50 μM at human iNOS, nNOS and eNOS respectively).
Useful References
Garvey et al (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 272:4959-63 abstract Thomsen et al (1997) Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res. 57:3300-4 abstract Hamilton et al (1998) Interactions between inducible isoforms of nitric oxide synthase and cyclo-oxygenase in vivo: investigations using the selective inhibitors, 1400W and celecoxib. Br J Pharmacol. 125:335-40 abstract
Chemical Information N-(3-(Aminomethyl)benzyl)acetamidine dihydrochloride
	Desiccate at +4°C MW 250.17 Soluble in water to 100 mM C₁₀H₁₅N₃.2HCl 180001-34-7