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1Kβ-Pompilidotoxin

Slows the Na+-channel inactivation

Other names: 1Kβ-PMTX

Product Code: Asc-1836

Purity: >98%

 
Pack Size

 

1mg

10mg

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Biological Description

Slows the Na+-channel inactivation. Mutated form of the β-Pompilidotoxin (Asc-1835). Slows the inactivation of TTX-sensitive Na+ channels. Selective for neuronal Na+ currents. Potentiates synaptic transmission in vivo with greater potency than α-Pompilidotoxin (Asc 1834) .

Useful References

beta-pompilidotoxin modulates spontaneous activity and persistent sodium currents in spinal networks. abstract

Isolation and structure of pompilidotoxins, novel peptide neurotoxins in solitary wasp venoms. abstract

Novel wasp toxin discriminates between neuronal and cardiac sodium channels. abstract

Chemical Information

KIKIGLFDQLSRL (Modifications: C-terminal amide)

Asc-1836
  • Desiccate at -20°C
  • MW 1531.00
  • Soluble in water
  • C71H124N20O17