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Ca2+ release modulator

Product Code: Asc-124

Purity: >98%

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Biological Description

Cell-permeable, allosteric inhibitor of D-myo-inositol 1,4,5-trisphosphate (IP3) -induced Ca2+ release . Inhibits IP3-induced Ca2+ release without affecting IP3 receptor binding. Blocks store operated Ca2+ entry.

Useful References

2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. abstract

(1997) 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J Biochem 122:498-505 abstract

(2002) Inhibition of the type 1 inositol 1,4,5-trisphosphate receptor by 2-aminoethoxydiphenylborate. Cell Signal 14:955-60 abstract

Chemical Information

2-Aminoethyl diphenylborinate

  • Desiccate at +4°C
  • MW 225.10
  • Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • C14H16BNO
  • 524-95-8