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3R12Rα-Pompilidotoxin

Voltage gated Na+ channel activator

Product Code: Asc-6034

Purity: >98%

 
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1mg

5mg

10mg

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Biological Description

Voltage gated Na+ channel activator. Slows TTX-sensitive channel inactivation without changing peak current-voltage relationship or the activation time course. Mutated form of α-Pompilidotoxin. 1Kβ-Pompilidotoxin (Asc-1836), 1Kα-Pompilidotoxin (Asc-6032) and 3R12Rα-Pompilidotoxin (Asc-6034) analog.

Useful References

Molecular determinants of binding of a wasp toxin (PMTXs) and its analogs in the Na+ channels proteins. abstract

A new class of neurotoxin from wasp venom slows inactivation of sodium current. abstract

Voltage-gated sodium channel isoform-specific effects of pompilidotoxins. abstract

Chemical Information

RIRIGLFDQLSRL (Modifications: C-terminal amide)

Asc-6034
  • Desiccate at -20°C
  • MW 1585.91
  • Soluble in aqueous buffer
  • C71H124N24O17