4-Aminopyridine (4-AP)

K⁺ channel blocker

Pack Size

Biological Description Potassium channel blocker. Blocks Kv channels. Convulsant, and useful tool to model epileptiform activity in vitro.
Useful References
(2005) International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol. Rev. 57:509-26 abstract (2007) The role of small-conductance Ca(2+)-activated K(+) channels in the modulation of 4-aminopyridine-induced burst firing in rat cerebellar Purkinje cells. Brain Res 1156:59-66 abstract Potassium channels--multiplicity and challenges. abstract
Citations
Molecular layer inhibitory interneurons provide feedforward and lateral inhibition in the dorsal cochlear nucleus abstract A new experimental model of focal seizures in the entorhinal cortex abstract An excitatory loop with astrocytes contributes to drive neurons to seizure threshold abstract Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling abstract
Chemical Information 4-Aminopyridine
	Store at RT MW 94.12 Soluble in water to 100 mM C₅H₆N₂ 504-24-5