8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP)
Cell permeable cAMP analogue, protein kinase modulatorOther names: 8-CPT-cAMP | |||||
Product Code: Asc-424 |
Purity: >98% |
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| Buy 8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP) from Abcam | ||||
Biological DescriptionMembrane permeable, lipophilic, cAMP analogue. Activator of Epac, cAMP and cGMP-dependent protein kinases (PKA/PKG). Displays site selectivity for Site B of cAMP-dependent PKA type II. Potently inhibits cyclic GMP-specific phosphodiesterase (PDE Va), PDE III and PDE IV (IC50 values are 0.9, 24 and 25μM respectively). Increases heart rate, causes fall in arterial blood pressure and vascular resistance in vivo. |
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Useful References | |
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). abstract Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells. abstract Blockade of beta-adrenoceptors enhances cAMP signal transduction in vivo. abstract | |
Chemical Information8-(4-Chlorophenylthio)-adenosine-3',5'-cyclic monophosphate sodium salt | |
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