AICAR (Acadesine/AICA riboside)
Cell-permeable activator of AMP-activated protein kinaseOther names: Acadesine / AICA riboside | |||||
Product Code: Asc-358 |
Purity: >98% |
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| Buy AICAR (Acadesine/AICA riboside) from Abcam | ||||
Biological DescriptionCell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro. |
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Useful References | |
Towler et al (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 100:328-41 abstract Gadalla et al (2004) Distinct mechanisms underlie the activation of rat brain AMP-activated protein kinase and the inhibition of excitatory synaptic transmission by AICA riboside (Acadesine) in area CA1 of rat hippocampus. J Neurochem. 88: 1272–1282 abstract Guigas et al (2009) Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. IUBMB Life. 61:18-26 abstract | |
Chemical Information5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide | |
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