AM404

Anandamide transport inhibitor

Pack Size

Biological Description Competitive and selective anandamide transport inhibitor (IC₅₀ = 1 μM). Active in vivo. Does not activate CB₁ receptors or inhibit anandamide hydrolysis but has been shown to activate vanilloid receptors.
Useful References
(1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277:1094-7 abstract (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396:39-42 abstract (2006) Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology. 2006 31:2652-9. abstract
Citations
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses abstract
Chemical Information (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)icosa-5,8,11,14-tetraenamide
	Desiccate at -20°C MW 395.58 Soluble in DMSO to 50 mM and in ethanol to 50 mM C₂₆H₃₇NO₂ 198022-70-7