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Alsterpaullone

Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor

Product Code: Asc-1070

Purity: >96%

 
Pack Size

 

1mg

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Biological Description

Potent CDK inhibitor (IC50 values are 3.5 (CDK1/cyclin B), 20 (CDK2/cyclin A) and 40 nM (CDK5/p35)). Also displays potent and selective inhibition of GSK-3β (IC50 values are 40 and 4 nM respectively). Antiproliferative effects seen in vitro. Cell-permeable.

Useful References

Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. abstract

Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. abstract

A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells. abstract

Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. abstract

Chemical Information

7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one

Asc-1070
  • Desiccate at +4°C
  • MW 293.28
  • C16H11N3O3
  • 237430-03-4