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Amiloride hydrochloride

eNaC blocker

Product Code: Asc-281

Purity: >99%

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Biological Description

Epithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na+/H+ exchange pathway. Also blocks transient reception potential cation (TRPC6 and TRPP3) channels.

Useful References

(2000) Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol. 62:573-94. abstract

(2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 72(6):1576-85. abstract

(1988) Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger. Biochimie. 70:1285-90 abstract

Chemical Information

N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

  • Store at RT
  • MW 266.09
  • Soluble in water to 10 mM (with heating) and in DMSO to 100 mM
  • C6H8ClN7O.HCl
  • 2016-88-8