Bafilomycin A1
Highly potent, selective (V)-ATPase inhibitorProduct Code: Asc-497 |
Purity: >98% |
||||
| Pack Size | |||||
| Buy Bafilomycin A1 from Abcam | ||||
Biological DescriptionHighly potent, selective vacuolar (V)-ATPase inhibitor (IC50 = 500 pM in chromaffin granule membranes). Induces vacuolar deacidification and promotes apoptosis. |
|
Useful References | |
Vacuolar ATPase as a drug discovery target. abstract Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. abstract Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. abstract | |
Chemical Information(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one | |
 |
|
