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Bisindolylmaleimide III

Potent PKC inhibitor. Inhibits S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency.

Product Code: Asc-4207

Purity: >98%

 
Pack Size

 

1mg

5mg

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Biological Description

Potent PKC inhibitor (IC50 = 26 nM, PKCα). Inhibits S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Inhibits GSK3β. Inhibits PDK1. Does not show TNFα-dependent apoptotic effects like Bisindolylmaleimide X (Asc-4211).

Useful References

Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool. abstract

Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. abstract

Activation of protein kinase C alpha enhances human growth hormone-binding protein release. abstract

Chemical Information

3-[1-(3-Aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione

Asc-4207
  • Desiccate at -20°C
  • MW 384.43
  • Soluble in ethanol and in DMSO
  • C23H20N4O2