α-Bungarotoxin

Subtype-selective α7 nAChR antagonist

Pack Size

Biological Description Irreversible antagonist of nicotinic acethylcholine receptors (nAChRs). 74-aa polypeptide derived from the venom of the banded krait, Bungarus multicinctus. Selective for α7 receptors over α3β4 receptors (IC₅₀ values are 1.6 nM and > 3 μM respectively). Blocks neuromuscular transmission. Inhibits opening of nicotinic receptor-associated ion channels.
Useful References
Neuronal nicotinic receptors: from structure to pathology. abstract Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. abstract Identification of regions involved in the binding of alpha-bungarotoxin to the human alpha7 neuronal nicotinic acetylcholine receptor using synthetic peptides. abstract
Chemical Information IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG disulfide bridges 3-23, 16-44, 29-33, 48-59, 60-65
	Desiccate at -20°C MW 7984.14 Soluble in any aqueous buffer. It is recommended that all preparations are centrifuged before use. C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁ 11032-79-4