CGP 37157

Na⁺-Ca²⁺ exchange inhibitor

Pack Size

Biological Description Selective inhibitor of the mitochondrial Na⁺-Ca²⁺ exchanger (IC₅₀ = 0.4 μM).
Useful References
(1997) CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 340:295 abstract (1993) Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange. TiPS 14:408 abstract (1993) Selectivity of inhibition of Na+-Ca2+ exchange of heart mitchondria by benzothiazepine CGP-37157. J.Cardiovascular.Pharmacol. 21:595 abstract
Citations
The physiological role of mitochondrial Na+/Ca2+ exchanger NCLX for glial Ca2+ homeostasis abstract Studying mitochondrial Ca2+ uptake – A revisit abstract Characterization of distinct single-channel properties of Ca2+ inward currents in mitochondria abstract
Chemical Information 7-Chloro-5-(2-chlorophenyl)-1,2,3,5-tetrahydro-4,1-benzothiazepin-2-one
	Desiccate at +4°C MW 324.22 Soluble in water to 5 mM, in ethanol to 100 mM and in DMSO to 100 mM C₁₅H₁₁Cl₂NOS 75450-34-9