CGP 57380
MNK inhibitorProduct Code: Asc-365 |
Purity: >98% |
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Biological DescriptionLow-molecular-weight kinase inhibitor of of MAP-kinase interacting kinase-1 (MNK1) and MNK2 (IC50 values are 0.87 and 1.6 μM respectively). Inhibits a range of other kinases (IC50 values in μM shown in brackets) including: CKI (0.51) Aurora B (2.5) DYRK3 (3.2) SGK1( 2.7) BRSK2 (1.1) and Lck (2.5). |
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Useful References | |
Knauf et al (2001) Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol Cell Biol. 21:5500-11. abstract Bain et al (2007)The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 408:297-315. abstract Tschopp et al (2000) Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies. Mol Cell Biol Res Commun. 3:205-211 abstract | |
Chemical InformationN-(4-Fluorophenyl)-1H-pyrazolo-[3,4-d]pyrimidine-3,4-diamine | |
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