Home > Cyclopiazonic acid from Penicillium grisefulvum 

Cyclopiazonic acid from Penicillium grisefulvum

Ca2+-ATPase inhibitor

Other names: α-Cyclopiazonic acid

Product Code: Asc-300

Purity: >99%

  
Pack Size

 

10mg

50mg
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Biological Description

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.
Useful References

Plenge-Tellechea et al (1997) On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid. J Biol Chem. 272:2794-800 abstract

Soler et al (1998) Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry. 37:4266-74 abstract

Laursen et al (2009) Cyclopiazonic Acid Is Complexed to a Divalent Metal Ion When Bound to the Sarcoplasmic Reticulum Ca2+-ATPase. J Biol Chem. 284:13513-8. abstract

Chemical Information

 (6aR,11aS,11bR)-10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one

Asc-300
  • Desiccate at -20°C
  • MW 336.38
  • Soluble in DMSO to 100 mM and in ethanol in 5 mM
  • C20H20N2O3
  • 18172-33-3
Additional Information

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