Cyclosporin A

PP2B inhibitor

Pack Size

Biological Description Immunosuppressant. Complexes with cyclophilin to inhibit the phosphatase activity of calcineurin (PP2B).
Useful References
Ho et al (1996) The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol. 80:S40-5 abstract Liu (1993) FK506 and cyclosporin: molecular probes for studying intracellular signal transduction. Trends Pharmacol Sci 14(5):182-8 abstract Yu et al (2006) Effects of cyclosporin A, FK506 and rapamycin on calcineurin phosphatase activity in mouse brain. IUBMB Life. 58:429-33 abstract
Chemical Information
	Desiccate at -20°C MW 1202.63 Soluble in DMSO to 100 mM and in ethanol to 50 mM C₆₂H₁₁₁N₁₁O₁₂ 59865-13-3