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D-AP5

NMDA glutamate site antagonist

Other names: APV / D-APV

Product Code: Asc-003

Purity: >99%

 
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Biological Description

Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5.

Also available in simple stock solutions (Asc-4482) - add 1 ml of water to get an exact, ready-to-use concentration.

Useful References

(2005) Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacol. 179:4 abstract

(1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75:65. abstract

(1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235:378 abstract

Citations

Bardoni et al. (2007) BDNF-mediated modulation of GABA and glycine release in dorsal horn lamina II from postnatal rats. Dev Neurobiol. 67:960-75. abstract

Trigo et al. (2007) Enhancement of GABA release through endogenous activation of axonal GABA(A) receptors in juvenile cerebellum. J Neurosci. 27:12452-63. abstract

Wulff et al. (2009) Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning abstract

Transition to addiction is associated with a persistent impairment in synaptic plasticity. abstract

Vesicular GABA release delays the onset of the Purkinje cell terminal depolarization without affecting tissue swelling in cerebellar slices during simulated ischemia. abstract

Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. abstract

Changes in NMDA receptor contribution to synaptic transmission in the brain in a rat model of glaucoma. abstract

New Tools for Understanding Epilepsy abstract

Synaptic vesicle endocytosis at a CNS nerve terminal: faster kinetics at physiological temperatures and increased endocytotic capacity during maturation abstract

Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition abstract

Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit abstract

Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus abstract

Involvement of amygdala dopamine and nucleus accumbens NMDA receptors in ethanol-seeking behavior in mice abstract

New evidence for purinergic signaling in the olfactory bulb: A2A and P2Y1 receptors mediate intracellular calcium release in astrocytes abstract

Mechanism of differential control of NMDA receptor activity by NR2 subunits abstract

Upregulation of inward rectifier K+ (Kir2) channels in dentate gyrus granule cells in temporal lobe epilepsy abstract

Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation abstract

Early development of the thalamic inhibitory feedback loop in the primary somatosensory system of the newborn mice abstract

Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3. 3 channels in Kcnc3-null mice requires Kcnc1 abstract

Short trains of theta frequency stimulation enhance CA1 pyramidal neuron excitability in the absence of synaptic potentiation abstract

Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex abstract

Glutamate‐mediated astrocyte‐to‐neuron signalling in the rat dorsal horn abstract

Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs abstract

Human cell-based micro electrode array platform for studying neurotoxicity abstract

Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus abstract

Distinctive properties of CXC chemokine receptor 4‐expressing Cajal–Retzius cells versus GABAergic interneurons of the postnatal hippocampus abstract

Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats abstract

Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia abstract

Simulated ischaemia induces Ca2+-independent glutamatergic vesicle release through actin filament depolymerization in area CA1 of the hippocampus abstract

Presynaptic inhibitory terminals are functionally abnormal in a rat model of posttraumatic epilepsy abstract

Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons abstract

Differential effects of Na+–K+ ATPase blockade on cortical layer V neurons abstract

Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex abstract

AMPA receptor activation controls type I metabotropic glutamate receptor signalling via a tyrosine kinase at parallel fibre–Purkinje cell synapses abstract

N‐arachidonyl‐glycine modulates synaptic transmission in superficial dorsal horn abstract

NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity abstract

Monosynaptic and polysynaptic feed-forward inputs to mitral cells from olfactory sensory neurons abstract

Neuronal network formation from reprogrammed early postnatal rat cortical glial cells abstract

Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells abstract

Stargazin (TARP γ-2) is required for compartment-specific AMPA receptor trafficking and synaptic plasticity in cerebellar stellate cells abstract

Components of neuronal chloride transport in rat and human neocortex abstract

Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat abstract

Distribution of extracellular glutamate in the neuropil of hippocampus abstract

Emetine treatment masks initial LTP without affecting long-term stability abstract

Critical and complex role of N-methyl-d-aspartate receptors in long-term depression at CA3–CA1 synapses in the developing hippocampus abstract

Interneuronal calcium channel abnormalities in posttraumatic epileptogenic neocortex abstract

Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons abstract

Single neuron firing properties impact correlation-based population coding abstract

P2Y 1 receptor activation by photolysis of caged ATP enhances neuronal network activity in the developing olfactory bulb abstract

Acoustic Overexposure Increases the Expression of VGLUT-2 Mediated Projections from the Lateral Vestibular Nucleus to the Dorsal Cochlear Nucleus abstract

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice abstract

Mixed inhibitory synaptic balance correlates with glutamatergic synaptic phenotype in cerebellar unipolar brush cells abstract

AMPA Receptor Activation Causes Silencing of AMPA Receptor-Mediated Synaptic Transmission in the Developing Hippocampus abstract

Tuning of synaptic integration in the medial entorhinal cortex to the organization of grid cell firing fields abstract

External tufted cells drive the output of olfactory bulb glomeruli abstract

A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-α abstract

Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses abstract

Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome abstract

Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus abstract

Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons abstract

Activation conditions for the induction of metabotropic glutamate receptor-dependent long-term depression in hippocampal CA1 pyramidal cells abstract

Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition abstract

Properties of urethral rhabdosphincter motoneurons and their regulation by noradrenaline abstract

A new mode of corticothalamic transmission revealed in the Gria4-/-model of absence epilepsy abstract

An intrinsic neural oscillator in the degenerating mouse retina abstract

Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition abstract

Purinergic signaling in the cerebellum: Bergmann glial cells express functional ionotropic P2X7 receptors abstract

Nerve terminal nAChRs initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca2+ channels and Ca2+ release … abstract

A continuous high frequency stimulation of the subthalamic nucleus determines a suppression of excitatory synaptic transmission in nigral dopaminergic neurons … abstract

Astrocyte signaling controls spike timing-dependent depression at neocortical synapses abstract

Abnormalities in hippocampal functioning with persistent pain abstract

Influence of a subtype of inhibitory interneuron on stimulus-specific responses in visual cortex abstract

Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers abstract

Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus abstract

Adaptation of Granule Cell to Purkinje Cell Synapses to High-Frequency Transmission abstract

Entorhinal theta-frequency input to the dentate gyrus trisynaptically evokes hippocampal CA1 LTP abstract

Mature and Precursor Brain-Derived Neurotrophic Factor Have Individual Roles in the Mouse Olfactory Bulb abstract

Impaired Chemosensitivity of Mouse Dorsal Raphe Serotonergic Neurons Overexpressing Serotonin 1A (Htr1a) Receptors abstract

Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms abstract

Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal … abstract

Physiological Concentrations of Choline Activate Native α7-Containing Nicotinic Acetylcholine Receptors in the Presence of PNU-120596 [1-(5-Chloro-2, 4- … abstract

Long-term depression at parallel fiber to Golgi cell synapses abstract

Heterosynaptic long-term potentiation at GABAergic synapses of spinal lamina I neurons abstract

κ-Opioid receptor inhibition of calcium oscillations in spinal cord neurons abstract

Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells abstract

Ca< sub> V 1 and Ca< sub> V 2 Channels Engage Distinct Modes of Ca< sup> 2+ Signaling to Control CREB-Dependent Gene Expression abstract

Cysteine string protein-α prevents activity-dependent degeneration in GABAergic synapses abstract

Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension abstract

mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus abstract

Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation abstract

Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes abstract

An excitatory loop with astrocytes contributes to drive neurons to seizure threshold abstract

Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors abstract

Glucose sensitivity of mouse olfactory bulb neurons is conveyed by a voltage-gated potassium channel. abstract

Evaluation of glutamate concentration transient in the synaptic cleft of the rat calyx of Held abstract

Activation of Group I Metabotropic Glutamate Receptors Potentiates Heteromeric Kainate Receptors abstract

Chondroitin sulfate, a major component of the perineuronal net, elicits inward currents, cell depolarization and calcium transients by acting on AMPA and kainate receptors of hippocampal neurons. abstract

Kainate Receptor Post-Translational Modifications Differentially Regulate Association with 4.1N to Control Activity-Dependent Receptor Endocytosis. abstract

Novel GABAergic Circuits Mediating Excitation/Inhibition of Cajal-Retzius Cells in the Developing Hippocampus abstract

Rapid, Activity-Independent Turnover of Vesicular Transmitter Content at a Mixed Glycine/GABA Synapse abstract

Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. abstract

Serotonergic modulation of neuronal activity in rat midbrain periaqueductal gray abstract

Synaptotagmin-12 Phosphorylation by cAMP-Dependent Protein Kinase Is Essential for Hippocampal Mossy Fiber LTP abstract

Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus abstract

Evidence for constitutive protein synthesis in hippocampal LTP stabilization. abstract

Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. abstract

Object-in-Place Associative Recognition Memory Depends on Glutamate Receptor Neurotransmission Within Two Defined Hippocampal-Cortical Circuits: A Critical Role for AMPA and NMDA Receptors in the Hippocampus, Perirhinal, and Prefrontal Cortices abstract

The dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor channels. abstract

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus. abstract

Sniffer patch laser uncaging response (SPLURgE): an assay of regional differences in allosteric receptor modulation and neurotransmitter clearance abstract

Real-Time Imaging of Amygdalar Network Dynamics In Vitro Reveals a Neurophysiological Link to Behavior in a Mouse Model of Extremes in Trait Anxiety abstract

Opposite actions of alcohol on tonic GABAA receptor currents mediated by nNOS and PKC activity. abstract

Chemical Information

D-(-)-2-Amino-5-phosphonopentanoic acid

Asc-003
  • Desiccate at +4°C
  • MW 197.13
  • Soluble in water to 100 mM
  • C5H12NO5P
  • 79055-68-8