DL-AP5
NMDA glutamate site antagonistProduct Code: Asc-004 |
Purity: >99% |
||||
| Pack Size | |||||
| Buy DL-AP5 from Abcam | ||||
Biological DescriptionCompetitive NMDA receptor glutamate site antagonist. Water-soluble form available - please see DL-AP5 sodium salt (Asc-271). |
|
Useful References | |
(1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75:65. abstract (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235:378. abstract (1981) Excitatory amino acid transmitters. Ann. Rev. Pharmacol. Toxicol. 21:165 abstract | |
Citations | |
Oren et al. (2009) Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons. J Neurosci 29(4):939-950 abstract Urbanski et al. (2009) Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. Synapse. 63(8):643-52. abstract Urbanski et al. (2010) Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. Neuroscience. 169(3):1268-78. abstract Slow glycinergic transmission mediated by transmitter pooling abstract Negative shift in the glycine reversal potential mediated by a Ca2+-and pH-dependent mechanism in interneurons abstract Lokalisation und Funktion des G-Protein gekoppelten Rezeptors GPR55 abstract Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1 abstract Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor abstract Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus abstract Kalirin loss results in cortical morphological alterations abstract Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl- … abstract Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit abstract Cell type‐specific and activity‐dependent dynamics of action potential‐evoked Ca2+ signals in dendrites of hippocampal inhibitory interneurons abstract The abused inhalant toluene differentially modulates excitatory and inhibitory synaptic transmission in deep-layer neurons of the medial prefrontal cortex abstract Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA … abstract Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension abstract Complex receptor mediation of acute ketamine application on< i> in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation … abstract Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1. 3 ion channel abstract Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology abstract Analysis of dendritic spine morphology in cultured CNS neurons abstract Age‐dependent remodelling of inhibitory synapses onto hippocampal CA1 oriens‐lacunosum moleculare interneurons abstract Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells abstract Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons abstract Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex abstract Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension abstract Enhancement of GABA release through endogenous activation of axonal GABAA receptors in juvenile cerebellum abstract Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus abstract Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral … abstract NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity abstract Cross-talk between P2X4 and γ-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse abstract Partial Disinhibition Is Required for Transition of Stimulus-Induced Sharp Wave–Ripple Complexes Into Recurrent Epileptiform Discharges in Rat Hippocampal Slices abstract Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits abstract Consolidation of remote fear memories involves corticotropin-releasing hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in … abstract Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase‐activated receptor‐2 abstract Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli abstract Purine receptor‐mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex abstract Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways abstract Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex abstract GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis abstract Disrupted-in-Schizophrenia (DISC1) Functions Presynaptically at Glutamatergic Synapses abstract A human mutation in gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors abstract Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation abstract Independent Regulation of Basal Neurotransmitter Release Efficacy by Variable Ca2+ Influx and Bouton Size at Small Central Synapses abstract Impaired Dendritic Expression and Plasticity of h-Channels in the< i> fmr1−/y Mouse Model of Fragile X Syndrome abstract Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis abstract Astrocytic activation and an inhibition of MAP kinases are required for proteinase‐activated receptor‐2‐mediated protection from neurotoxicity abstract Fidelity of complex spike-mediated synaptic transmission between inhibitory interneurons abstract | |
Chemical InformationDL-2-Amino-5-phosphonopentanoic acid | |
| |
