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DL-AP5

NMDA glutamate site antagonist

Product Code: Asc-004

Purity: >99%

 
Pack Size

 

10mg

50mg

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Biological Description

Competitive NMDA receptor glutamate site antagonist. Water-soluble form available - please see DL-AP5 sodium salt (Asc-271).

Useful References

(1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75:65. abstract

(1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235:378. abstract

(1981) Excitatory amino acid transmitters. Ann. Rev. Pharmacol. Toxicol. 21:165 abstract

Citations

Oren et al. (2009) Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons. J Neurosci 29(4):939-950 abstract

Urbanski et al. (2009) Depolarizing GABAergic synaptic input triggers endocannabinoid-mediated retrograde synaptic signaling. Synapse. 63(8):643-52. abstract

Urbanski et al. (2010) Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. Neuroscience. 169(3):1268-78. abstract

Slow glycinergic transmission mediated by transmitter pooling abstract

Negative shift in the glycine reversal potential mediated by a Ca2+-and pH-dependent mechanism in interneurons abstract

Lokalisation und Funktion des G-Protein gekoppelten Rezeptors GPR55 abstract

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1 abstract

Cell type-specific long-term plasticity at glutamatergic synapses onto hippocampal interneurons expressing either parvalbumin or CB1 cannabinoid receptor abstract

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus abstract

Kalirin loss results in cortical morphological alterations abstract

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl- … abstract

Synapse-specific inhibitory control of hippocampal feedback inhibitory circuit abstract

Cell type‐specific and activity‐dependent dynamics of action potential‐evoked Ca2+ signals in dendrites of hippocampal inhibitory interneurons abstract

The abused inhalant toluene differentially modulates excitatory and inhibitory synaptic transmission in deep-layer neurons of the medial prefrontal cortex abstract

Presynaptic induction and expression of timing-dependent long-term depression demonstrated by compartment-specific photorelease of a use-dependent NMDA … abstract

Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension abstract

Complex receptor mediation of acute ketamine application on< i> in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation … abstract

Mitral cells of the olfactory bulb perform metabolic sensing and are disrupted by obesity at the level of the Kv1. 3 ion channel abstract

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology abstract

Analysis of dendritic spine morphology in cultured CNS neurons abstract

Age‐dependent remodelling of inhibitory synapses onto hippocampal CA1 oriens‐lacunosum moleculare interneurons abstract

Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells abstract

Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons abstract

Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex abstract

Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension abstract

Enhancement of GABA release through endogenous activation of axonal GABAA receptors in juvenile cerebellum abstract

Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus abstract

Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral … abstract

NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity abstract

Cross-talk between P2X4 and γ-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse abstract

Partial Disinhibition Is Required for Transition of Stimulus-Induced Sharp Wave–Ripple Complexes Into Recurrent Epileptiform Discharges in Rat Hippocampal Slices abstract

Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits abstract

Consolidation of remote fear memories involves corticotropin-releasing hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in … abstract

Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase‐activated receptor‐2 abstract

Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli abstract

Purine receptor‐mediated endocannabinoid production and retrograde synaptic signalling in the cerebellar cortex abstract

Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways abstract

Exogenous and endogenous cannabinoids suppress inhibitory neurotransmission in the human neocortex abstract

GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis abstract

Disrupted-in-Schizophrenia (DISC1) Functions Presynaptically at Glutamatergic Synapses abstract

A human mutation in gabrg2 associated with generalized epilepsy alters the membrane dynamics of GABAA receptors abstract

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation abstract

Independent Regulation of Basal Neurotransmitter Release Efficacy by Variable Ca2+ Influx and Bouton Size at Small Central Synapses abstract

Impaired Dendritic Expression and Plasticity of h-Channels in the< i> fmr1−/y Mouse Model of Fragile X Syndrome abstract

Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis abstract

Astrocytic activation and an inhibition of MAP kinases are required for proteinase‐activated receptor‐2‐mediated protection from neurotoxicity abstract

Fidelity of complex spike-mediated synaptic transmission between inhibitory interneurons abstract

Input-specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons. abstract

Reduced GABAA Receptor-Mediated Tonic Inhibition in Aged Rat Auditory Thalamus. abstract

Medial Prefrontal Cortex Inversely Regulates Toluene-Induced Changes in Markers of Synaptic Plasticity of Mesolimbic Dopamine Neurons abstract

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2 abstract

Small conductance Ca2+-activated K+ channels modulate action potential-induced Ca2+ transients in hippocampal neurons. abstract

5-HT₁A receptors direct the orientation of plasticity in layer 5 pyramidal neurons of the mouse prefrontal cortex. abstract

Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons abstract

Learning-Related Translocation of -Opioid Receptors on Ventral Striatal Cholinergic Interneurons Mediates Choice between Goal-Directed Actions abstract

The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex. abstract

Chemical Information

DL-2-Amino-5-phosphonopentanoic acid

Asc-004
  • Desiccate at +4°C
  • MW 197.13
  • Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM
  • C5H12NO5P
  • 76326-31-3