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Dynole-34-2™

Potent dynamin I and dynamin II inhibitor

Product Code: Asc-463

Purity: >98%

  
Pack Size

 

5mg
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Biological Description

Potent, cell permeable dynamin I and dynamin II inhibitor (IC50 = 1.3 and 14.2 µM for inhibition of Dynamin I and II GTPase respectively). Targets the GTPase domain at an allosteric site. Potently inhibits receptor-mediated and synaptic vesicle endocytosis (IC50 values are 5 and 41.1 µM respectively). 15-fold more active than Dynasore (Asc-192) against dynamin I.
Useful References

Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. abstract

Chemical Information

2-Cyano-N-octyl-3-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]acrylamide

Asc-463
  • Desiccate at +4°C
  • MW 408.59
  • Soluble in DMSO to 100 mM
  • C25H36N4O
Additional Information

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dynole-34-2™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.