FCCP

Mitochondrial oxidative phosphorylation inhibitor

Pack Size

Biological Description A potent reversible inhibitor of mitochondrial oxidative phosphorylation. Depolarises mitochondrial membrane potential and induces apoptosis.
Useful References
(1983) The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone). Biophys J. 41:381-98 abstract (2000) Inositol 1,4,5-trisphosphate-induced Ca2+ release is inhibited by mitochondrial depolarization. Biochem J. 347:593-600 abstract (2000) A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells. Neuroreport. 11:2953-6. abstract
Citations
The physiological role of mitochondrial Na+/Ca2+ exchanger NCLX for glial Ca2+ homeostasis abstract
Chemical Information Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
	Desiccate at +4°C MW 254.17 Soluble in DMSO to 100 mM C₁₀H₅F₃N₄O 370-86-5