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Flecainide

Sodium channel blocker

Product Code: Asc-504

Purity: >99%

 
Pack Size

 

10mg

50mg

Buy Flecainide from Abcam
Biological Description

Sodium channel blocker. Class IC antiarrhythmic agent. Inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Also inhibits cardiac ryanodine receptors. Orally-active.

Useful References

The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions. abstract

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. abstract

Use- and concentration-dependent effects of flecainide in guinea pig right ventricular muscle. abstract

Chemical Information

(RS)-N-(Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Asc-504
  • Desiccate at +4°C
  • MW 414.34
  • Soluble in ethanol to 100 mM and in DMSO to 50 mM
  • C17H20F6N2O3
  • 54143-55-4