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Forskolin

Adenylyl cyclase activator

Product Code: Asc-058

Purity: >98%

  
Pack Size

 

10mg

50mg

100mg
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Biological Description

Cell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. Positive inotropic, platelet anti-aggregatory and anti-hypertensive actions in vivo.
Useful References

(1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258:2960. abstract

(1983) Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26 436. abstract

Citations

Gandia et al. (2008) Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique. FEBS 582: 2979-2984 abstract

Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of Rett syndrome abstract

Exploring the Structure, Function & Regulation of the Human Glucagon-Like Peptide-1 Receptor abstract

EFFECT OF CYCLIC ADENOSINE MONOPHOSPHATE ON THE G PROTEIN-DEPENDENT INWARD RECTIFIER K+-LIKE CHANNEL CURRENT IN MEDIAL … abstract

Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent … abstract

Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon abstract

Chemical Information

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-1H-benzo[f]chromen-5-yl acetate

Asc-058
  • Desiccate at -20°C
  • MW 410.50
  • Soluble in ethanol to 10 mM and in DMSO to 25 mM
  • C22H34O7
  • 66575-29-9