Forskolin

Adenylyl cyclase activator

Pack Size

Biological Description Cell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. Positive inotropic, platelet anti-aggregatory and anti-hypertensive actions in vivo.
Useful References
Laurenza et al (1989) Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? 10:442-7 abstract Awad et al (1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258:2960. abstract Seamon et al (1983) Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26 436. abstract
Citations
Gandia et al. (2008) Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique. FEBS 582: 2979-2984 abstract
Chemical Information (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-1H-benzo[f]chromen-5-yl acetate
	Desiccate at -20°C MW 410.50 Soluble in DMSO to 25 mM and in ethanol to 10 mM C₂₂H₃₄O₇ 66575-29-9