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Gabapentin

α2δ ligand

Product Code: Asc-219

Purity: >99%

  
Pack Size

 

10mg

50mg
Buy Gabapentin from Abcam
Biological Description

Interacts with the α2δ subunit of L-type voltage gated Ca2+ channels. Disrupts calcium channel trafficking. Anticonvuslant and analgesic in vivo.
Useful References

(2008) Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. Proc Natl Acad Sci U S A. 105:3628-33 abstract

CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: The calcium channel a2-d (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007;73:137–150. abstract

(2006) The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol. 6:108-13 abstract

Chemical Information

2-[1-(Aminomethyl)cyclohexyl]acetic acid

Asc-219
  • Desiccate at +4°C
  • MW 171.24
  • Soluble in water to 100 mM
  • C9H17NO2
  • 60142-96-3