H89 dihydrochloride

Kinase inhibitor

Pack Size

Biological Description Kinase inhibitor, commonly used as a protein kinase A inhibitor (IC₅₀ = 135 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII (IC₅₀ values are 120 nM, 80 nM and 270 nM respectively).
Useful References
Lochner et al (2006) The many faces of H89: a review. Cardiovasc Drug Rev. 24:261-74 abstract Davies et al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. 351:95-105. abstract
Chemical Information N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-Isoquinolinesulfonamide dihydrochloride
	Desiccate at -20°C MW 519.28 Soluble in water to 25 mM and in DMSO to 100 mM C₂₀H₂₀BrN₃O₂S.HCl 127243-85-0