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Hainantoxin-IV

Potent, selective TTX-sensitive voltage-gated Na+ channel blocker

Product Code: Asc-6038

Purity: >98%

 
Pack Size

 

50µg

100µg

500µg

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Biological Description

Potent, selective TTX-sensitive voltage-gated Na+ channel blocker (IC50 = 45 nM). Hainantoxin-III (Asc-6037) analog. Shows analgesic effects in vivo.

Useful References

A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels. abstract

Synthesis and analgesic effects of mu-TRTX-Hhn1b on models of inflammatory and neuropathic pain. abstract

Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV. abstract

Chemical Information

ECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCKYEI (Modifications: C-terminal amide; Disulfide bonds: 2-17, 9-24, 16-31)

Asc-6038
  • Desiccate at -20°C
  • MW 3987.54
  • Soluble in aqueous buffer
  • C166H257N53O50S6