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ICI 182,780

Estrogen receptor antagonist

Other names: Fulvestrant

Product Code: Asc-131

Purity: >99%

 
Pack Size

 

10mg

50mg

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Biological Description

Estrogen receptor antagonist with no partial agonist activity. Anticancer agent (IC50 = 0.29 nM for inhibition of breast cancer cell growth). Causes downregulation and loss of estrogen receptors.

Useful References

(2001) Induction of apoptosis in mammary gland by a pure anti-estrogen ICI 182780. Breast Cancer Res Treat. 68:127-38 abstract

Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. abstract

(1991) A potent specific pure antiestrogen with clinical potential. Cancer Res 51:3867-73 abstract

Citations

A novel first exon directs hormone-sensitive transcription of the pig prolactin receptor abstract

Chemical Information

(7R,9S,13S,14S,17S)-7-(9-(4,4,5,5,5-Pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-6H-cyclopenta[a]phenanthrene-3,17-diol

Asc-131
  • Store at RT
  • MW 606.77
  • Soluble in DMSO to 100 mM and in ethanol to 50 mM
  • C32H47F5O3S
  • 129453-61-8