ICI 182,780

Estrogen receptor antagonist

Pack Size

Biological Description Estrogen receptor antagonist with no partial agonist activity. Anticancer agent (IC₅₀ = 0.29 nM for inhibition of breast cancer cell growth). Causes downregulation and loss of estrogen receptors.
Useful References
(2001) Induction of apoptosis in mammary gland by a pure anti-estrogen ICI 182780. Breast Cancer Res Treat. 68:127-38 abstract Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. abstract (1991) A potent specific pure antiestrogen with clinical potential. Cancer Res 51:3867-73 abstract
Chemical Information (7R,9S,13S,14S,17S)-7-(9-(4,4,5,5,5-Pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-6H-cyclopenta[a]phenanthrene-3,17-diol
	Store at RT MW 606.77 Soluble in DMSO to 100 mM and in ethanol to 50 mM C₃₂H₄₇F₅O₃S 129453-61-8