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Iminodyn-22™

Potent, broad spectrum dynamin inhibitor

Product Code: Asc-461

Purity: >98%

  
Pack Size

 

5mg
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Biological Description

Potent, broad spectrum dynamin inhibitor. (IC50 values are 450 nM and 390 nM for inhibition of dynamin I and II GTPase respectively). Binds to the GTPase domain at an allosteric site and displays uncompetitive antagonism with respect to GTP. Inhibits receptor mediated endocytosis (RME) and synaptic vesicle endocytosis (SVE) (IC50 values are 10.7 and 108 µM respectively).
Useful References

Changes in the key odorants of Italian Hazelnuts ( Coryllus avellana L. Var. Tonda Romana) induced by roasting. abstract

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. abstract

Chemical Information

N,N'-(Propane-1,3-diyl)bis(7,8-dihydroxy-2-imino-2H-chromene-3-carboxamide)

Asc-461
  • Desiccate at +4°C
  • MW 480.43
  • Soluble in DMSO to 25 mM
  • C23H20N4O8
Additional Information

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Iminodyn-22™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.