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Potent cyclin-dependent kinase and GSK-3β inhibitor

Product Code: Asc-960

Purity: >98%

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Biological Description

Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.

Useful References

Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. abstract

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? abstract

Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells. abstract

Chemical Information


  • Desiccate at -20°C
  • MW 262.27
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • C16H10N2O2
  • 479-41-4