Iodotubercidin
Potent, adenosine kinase inhibitorProduct Code: Asc-452 |
Purity: >95% |
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Biological DescriptionPotent, specific adenosine kinase inhibitor (IC50 = 26 nM). Inhibits platelet aggregation and spreading, and interferes with adenosine and adenine nucleotide metabolism. Additionally inhibits other kinases such as ERK2 (Ki = 525 nM). |
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Useful References | |
Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. abstract Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. abstract Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. abstract | |
Chemical Information5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | |
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