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Kynurenic acid

Endogenous ionotropic / nicotinic antagonist

Product Code: Asc-064

Purity: >99%

 
Pack Size

 

1g

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Biological Description

Endogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (#Asc-256)

Useful References

(1997) The kynurenate test, a biochemical assay for putative cognition enhancers. J Pharmacol Exp Ther. 283:82-90 abstract

(1994) Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res. 655:91-6. abstract

(2006) Modulation of the function of presynaptic α7 and non-α7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. Br J Pharmacol. 149:724-32 abstract

Citations

Adenosine signalling at immature parallel fibre–Purkinje cell synapses in rat cerebellum abstract

Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress- … abstract

Desynchronization of multivesicular release enhances Purkinje cell output abstract

Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses abstract

Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice abstract

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia abstract

A new experimental model of focal seizures in the entorhinal cortex abstract

Development of adenosine signalling in the cerebellum abstract

The dynamics of single spike-evoked adenosine release in the cerebellum abstract

Insulin Reduces Neuronal Excitability by Turning on GABAA Channels that Generate Tonic Current abstract

Chemical Information

4-Hydroxyquinoline-2-carboxylic acid

Asc-064
  • Store at RT
  • MW 189.17
  • Soluble in 1 eq. NaOH to 100 mM and in DMSO to 50 mM
  • C10H7NO3
  • 492-27-3