Kynurenic acid
Endogenous ionotropic / nicotinic antagonistProduct Code: Asc-064 |
Purity: >99% |
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| Buy Kynurenic acid from Abcam | |||
Biological DescriptionEndogenous antagonist at ionotropic, glycine β and α7 nicotinic receptors. Neuroprotective in vivo. Water-soluble form available - please see Kynurenic acid sodium salt (#Asc-256) |
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Useful References | |
(1997) The kynurenate test, a biochemical assay for putative cognition enhancers. J Pharmacol Exp Ther. 283:82-90 abstract (1994) Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res. 655:91-6. abstract (2006) Modulation of the function of presynaptic α7 and non-α7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. Br J Pharmacol. 149:724-32 abstract | |
Citations | |
Adenosine signalling at immature parallel fibre–Purkinje cell synapses in rat cerebellum abstract Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress- … abstract Desynchronization of multivesicular release enhances Purkinje cell output abstract Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses abstract Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice abstract A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia abstract A new experimental model of focal seizures in the entorhinal cortex abstract Development of adenosine signalling in the cerebellum abstract The dynamics of single spike-evoked adenosine release in the cerebellum abstract Insulin Reduces Neuronal Excitability by Turning on GABAA Channels that Generate Tonic Current abstract | |
Chemical Information4-Hydroxyquinoline-2-carboxylic acid | |
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