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Selective group III mGlu agonist

Product Code: Asc-002

Purity: >99%

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Biological Description

Selective group III mGlu receptor agonist.

Also available in simple stock solutions (Asc-4481) - add 1 ml of water to get an exact, ready-to-use concentration.

Useful References

(1982) The effect of a series of omega-phosphonic-alpha-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75:65. abstract

(1995) The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4α, is determined by the N-terminal extracellular domain. NeuroReport 7:117 abstract

(1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacol. 38:143. abstract


Lopez et al. (2007) Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease. J Neurosci. 27: 6701-11. abstract

Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4 abstract

Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated abstract

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists abstract

Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7 abstract

Interdomain movements in metabotropic glutamate receptor activation abstract

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential abstract

mGluR control of interneuron output regulates feedforward tonic GABAA inhibition in the visual thalamus abstract

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner abstract

Deletion of Ecto-5?-Nucleotidase (CD73) Reveals Direct Action Potential-Dependent Adenosine Release abstract

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia abstract

Development of adenosine signalling in the cerebellum abstract

Inhibitory mechanisms that generate centre and surround properties in ON and OFF brisk-sustained ganglion cells in the rabbit retina abstract

ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization abstract

Chemical Information

L-(+)-2-Amino-4-phosphonobutyric acid

  • Desiccate at +4°C
  • MW 183.10
  • Soluble in water to 100 mM
  • C4H10NO5P
  • 23052-81-5