LY 294002

PI3-kinase inhibitor

Pack Size

Biological Description A highly selective inhibitor of phosphatidylinositol 3-kinase (IC₅₀ = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAP kinase and PI4- kinase (IC₅₀ > 50 μM).
Useful References
(1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 269:5241-8 abstract (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 404:15-21 abstract (2000) Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell. 6:909-1 abstract
Citations
Modulation of neuronal maturation: influence of neurotrophic factors and neuromodulators abstract Regulation and function of Cav3. 1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells abstract
Chemical Information 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one
	Desiccate at +4°C MW 307.35 Soluble in DMSO to 25 mM and in ethanol to 5 mM C₁₉H₁₇NO₃ 154447-36-6