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Licarbazepine (10,11-Dihydro-10-hydroxycarbamazepine)

Active oxcarbazepine metabolite

Other names: 10,11-Dihydro-10-hydroxycarbamazepine

Product Code: Asc-5867

Purity: >99%

 
Pack Size

 

10mg

50mg

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Biological Description

Active metabolite of oxcarbazepine (Asc-1827). Induces microsomal enzymes via sodium channel protein inhibition. Potentiates minor GABAA receptor currents; exhibits anticonvulsant activity. Antiepileptic agent. Active in vivo.

Useful References

Pharmacokinetics of licarbazepine in healthy volunteers: single and multiple oral doses and effect of food. abstract

Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. abstract

Oxcarbazepine in bipolar disorder: a critical review of the literature. abstract

Chemical Information

10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide

Asc-5867
  • Desiccate at -20°C
  • MW 254.28
  • Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • C15H14N2O2
  • 29331-92-8