Lovastatin (Mevinolin)

Potent HMG CoA reductase inhibitor

Pack Size

Biological Description Potent, competitive HMG CoA reductase inhibitor (K_i = 0.6 nM). Blood brain barrier permeable. Inhibits in vivo and in vitro cholesterol biosynthesis. Also reduces α-synuclein levels in vitro and in vivo.
Useful References
Purification and characterization of 3-hydroxymethylglutaryl-coenzyme A reductase of Schistosoma mansoni: regulation of parasite enzyme activity differs from mammalian host. abstract Lovastatin, an inhibitor of cholesterol synthesis, induces hydroxymethylglutaryl-coenzyme A reductase directly on membranes of expanded smooth endoplasmic reticulum in rat hepatocytes. abstract Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. abstract
Chemical Information (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate
	Desiccate at +4°C MW 404.54 Soluble in DMSO to 100 mM and in ethanol to 50 mM C₂₄H₃₆O₅ 75330-75-5