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MiTMAB™

Cell permeable dynamin I and dynamin II inhibitor

Product Code: Asc-466

  
Pack Size

 

5mg
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Biological Description

Cell permeable dynamin I and dynamin II inhibitor (IC50  = 3.1 and 8.4 µM for inhibition of dynamin I and dynamin II GTPase respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and noncompetitive with GTP. Inhibits receptor-mediated and synaptic vesicle endocytosis (IC50  values are 19.9 and 2.2 µM respectively). Inhibits cancer cell growth.
Useful References

Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. abstract

Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. abstract

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. abstract

Chemical Information

Tetradecyltrimethylammonium bromide

Asc-466
  • Desiccate at RT
  • MW 336.40
  • Soluble in water to 100 mM
  • C17H38BrN
  • 1119-97-7
Additional Information

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. MiTMAB™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd