N-Desmethyl clozapine (Normethylclozapine)
Clozapine metabolite. M1 agonist. D2/D3 agonist.Other names: Normethylclozapine | |||||
Product Code: Asc-026 |
Purity: >99% |
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| Buy N-Desmethyl clozapine (Normethylclozapine) from Abcam | ||||
Biological DescriptionBrain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5HT1 and 5HT2. |
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Useful References | |
(2003) N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A. 100:13674 abstract (1996) Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur.J.Pharamcol. 301:27 abstract (2005) Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J.Pharmacol Exp Ther. 315:1278 abstract | |
Chemical Information8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine | |
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