N^ω-Nitro-L-arginine Methyl Ester hydrochloride (L-NAME)

NOS inhibitor

Pack Size

Biological Description Cell permeable NOS inhibitor. More soluble analogue of arginine. (pIC₅₀ values are 4.3, 5.7 and 5.6 at human iNOS, nNOA and eNOS respectively).
Useful References
Moncada et al (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-42 abstract Moore & Handy (1997) Selective inhibitors of neuronal nitric oxide synthase--is no NOS really good NOS for the nervous system? Trends Pharmacol Sci 18:204-11 abstract Boer et al (2000) The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes. Mol Pharmacol. 58:1026-34 abstract
Chemical Information N^ω-Nitro-L-arginine methyl ester hydrochloride
	Desiccate at +4°C MW 269.69 Soluble in water to 100 mM C₇H₁₅N₅O₄.HCl 51298-62-5

Nω-Nitro-L-arginine Methyl Ester hydrochloride (L-NAME)