N⁶-Cyclopentyladenosine (CPA)

Potent, selective A₁ agonist

Pack Size

Biological Description Potent and selective adenosine A₁ receptor agonist (K_i values are 2.3, 790 and 43 nM for human A₁, A_2A and A₃ receptors respectively). Centrally active following systemic administration in vivo. Anticonvulsant, with cardiovacular actions, and effects on sleep regulation.
Useful References
(1986) Evaluation of the binding of the A-1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue. Naunyn Schmiedebergs Arch Pharmacol. 332:179-83 abstract (2000) Adenosine receptors and their ligands. Naunyn-Schmied Arch Pharmacol 362:382-91 abstract al (1996) Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat. Eur J Pharmacol. 300:163-71. abstract
Citations
GABA is depolarizing in hippocampal dentate granule cells of the adolescent and adult rats abstract Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells abstract Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells abstract Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors abstract
Chemical Information N-Cyclopentyladenosine
	Desiccate at +4°C MW 335.36 Soluble in 1 eq. HCl to 100 mM, in DMSO to 100 mM and in ethanol to 25 mM (with warming) C₁₅H₂₁N₅O₄ 41552-82-3

N6-Cyclopentyladenosine (CPA)