NS 398
COX-2 inhibitorProduct Code: Asc-295 |
Purity: >98% |
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| Buy NS 398 from Abcam | ||||
Biological DescriptionSelective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Orally active. Anti-inflammatory, anti-pyretic, analgesic and non-ulcerogenic in vivo. Induces apoptosis and cell cycle arrest. |
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Useful References | |
Futaki et al (1994) NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 47:55-9 abstract Futaki et al (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 24:105–110 abstract Du et al (2008) Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncol Rep. 20:605-11 abstract | |
Chemical InformationN-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide | |
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