ODQ

Selective, potent inhibitor of NO-sensitive guanylyl cyclase

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Biological Description Selective, potent inhibitor of nitric oxide-sensitive guanylyl cyclase.
Useful References
Garthwaite et al (1995) Potent and selective inhibition of nitric oxide sensitive guanylyl cyclase by 1H[1,2,4]oxadiazolo[4,3a]quinoxalin-1-one. Mol. Pharmacol. 48:184 abstract Schrammel et al (1996) Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol.Pharmacol. 50:1 abstract Homer et al (1999) Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation. J.Pharm.Pharmacol. 51:135 abstract
Chemical Information 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
	Desiccate at +4°C MW 187.16 Soluble in DMSO to 100 mM and in ethanol to 25 mM C₉H₅N₃O₂ 41443-28-1