OcTMAB™

Cell permeable dynamin I and dynamin II inhibitor

Product Code: Asc-467

Purity: >98%

Pack Size

5mg

Biological Description

Cell permeable dynamin I and dynamin II inhibitor (IC₅₀ = 1.9 and 4.4 µM for inhibition of dynamin I and II GTPase respectively). Targets the pleckstrin homology (PH) (lipid binding) domain. Competitive with phospholipid and noncompetitive with GTP. Inhibits receptor-mediated endocytosis (IC₅₀ = 6.7 µM). Inhibits cancer cell growth.

Useful References

Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II abstract

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. abstract

Chemical Information

Octadecyltrimethylammonium bromide

Desiccate at RT
MW 392.51
Soluble in DMSO to 25 mM (with warming)
C₂₁H₄₆BrN
1120-02-1

Additional Information

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. OcTMAB™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.