Okadaic acid
PP1 and PP2A inhibitorProduct Code: Asc-375 |
Purity: >98% |
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Biological DescriptionPotent inhibitor of protein phosphatase 1 (IC50 = 3 - 15 nM) and protein phosphatase 2A (IC50 = 0.1-1 nM). Highly selective over PP2B, PP2C and a range of other phosphatases. Tumor promotor. |
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Useful References | |
Fernandez et al (2002) Okadaic acid, useful tool for studying cellular processes. Curr Med Chem. 9:229-62 abstract Cohen et al (1990) Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem Sci. 15:98-102 abstract Haystead et al (1989) Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature. 337:78-81. abstract | |
Chemical Information9,10-Deepithio-9,10-didehydroacanthifolicin | |
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