PNU 120596

Positive allosteric modulator for the α7 nicotinic acetylcholine receptor

Pack Size

Biological Description Competitive, type II positive allosteric modulator for α7nAChR (EC₅₀ = 216 nM). Increases potency of nicotinic agonists. No effect on α4β2, α3β4 and α9α10 nAChRs. Active in vivo.
Useful References
Competitive binding at a nicotinic receptor transmembrane site of two a7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization. abstract alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex. abstract A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. abstract
Chemical Information N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)urea
	Desiccate at +4°C MW 311.72 Soluble in DMSO to 100 mM C₁₃H₁₄ClN₃O₄ 501925-31-1