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Phenytoin

Na+ channel blocker

Product Code: Asc-3201

Purity: >99%

 
Pack Size

 

50mg

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Biological Description

Na+ channel blocker. Reduces Na+ channel availability. Decreases action potential amplitude with minimal effect on frequency. Phenytoin sodium (Asc-3200) analog. Shows anticonvulsant, antiarrhythmic and muscle relaxant effects in vivo. Orally active.

Useful References

Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (CAS No. 57-41-0) (Phenytoin) in F344/N Rats and B6C3F1 Mice (Feed Studies). abstract

Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin. abstract

Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. abstract

Chemical Information

5,5-Diphenylimidazolidine-2,4-dione

Asc-3201
  • Desiccate at +4°C
  • MW 252.27
  • Soluble in water to 25 mM (with warming) and in DMSO to 25 mM

  • C15H12N2O2
  • 57-41-0