Phorbol 12-myristate 13-acetate (PMA)
PKC activatorOther names: PMA | ||||||
Product Code: Asc-297 |
Purity: >99% |
|||||
| Pack Size | ||||||
| Buy Phorbol 12-myristate 13-acetate (PMA) from Abcam | |||||
Biological DescriptionPotent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non kinase proteins including chimaerins, RasGRP and Unc-13/Munc-13. Extremely potent mouse skin tumor promoter. |
|
Useful References | |
Ryves et al (1991) Activation of the PKC-isotypes alpha, beta 1, gamma, delta and epsilon by phorbol esters of different biological activities. FEBS Lett. 288:5-9 abstract Kazanietz (2000) Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol Carcinog. 28:5-11 abstract Kazanietz et al (2000) Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. Biochem Pharmacol. 60:1417-24 abstract | |
Chemical InformationPhorbol 12-myristate 13-acetate | |
 |
|
